Spatial transcriptomics
Where each chondrocyte state sits in the tissue. Single-cell and spatial omics mapped onto the zones.
CRIP1+ prehypertrophic chondrocytes: spatial transcriptomics confirms co-localization with prefibroblasts in OA
Spatial data places CRIP1+ preHTC at pathological niches alongside prefibroblasts; confirmed as diagnostic candidate
OA single-cell and spatial transcriptomics: pathway regulation, cell interaction networks, therapeutic translation
August 2026 review integrating scRNA-seq and spatial data for OA; identifies actionable pathway targets
Multi-omics integration in osteoarthritis: cell-type-specific gene-metabolite networks for precision medicine (Review)
Review joining transcriptomic and metabolomic layers by cell type in OA.